EOSINOPHILIC IMMUNE DYSFUNCTION
ACROSS INFLAMMATORY DISEASES

HYPER-EOSINOPHILIC SYNDROME (HES)

Eosinophilic
asthma (EA)

Chronic rhinosinusitis with nasal polyps (CRSwNP)

Eosinophilic
esophagitis (EoE)

Eosinophilic granulomatosis with polyangiitis (EGPA)

Hyper eosinophilic
syndrome (HES)

WHAT IS HYPER-EOSINOPHILIC SYNDROME (HES)?

Hyper-eosinophilic syndrome (HES) is a rare disease and defined by persistent hyper-eosinophilia (>1500 per microliter) and evidence of eosinophil-mediated organ damage or dysfunction.1,2

Potentially fatal disorders associated with HES include1:

 

Potential Fatal Disorders Associated with HES
Potential Fatal Disorders Associated with HES

 

THE ROLE OF EOSINOPHILIC IMMUNE DYSFUNCTION IN HYPER-EOSINOPHILIC SYNDROME

Dysregulation of biological mechanisms involved in eosinophil
recruitment and activation can lead to end-organ damage due to
eosinophil-mediated tissue damage.2

 

CLINICAL CONSEQUENCES OF HYPER-EOSINOPHILIC SYNDROME (HES)

Hyper-eosinophilic syndrome can manifest as tissue-specific or
widespread organ damage, resulting in diverse symptoms. Worsening of
clinical features, or flares, can occur during treatment or
upon withdrawal.3

 

Organ involvement in hypereosinophilic sydnrome2

Organ Involvement in Hyper-Eosinophilic Syndrome
Organ Involvement in Hyper-Eosinophilic Syndrome

*Includes cardiac and vascular involvement1.

ASTRAZENECA IS COMMITTED TO UNCOVERING THE ROLE OF EOSINOPHILIC IMMUNE DYSFUNCTION IN HYPER-EOSINOPHILIC SYNDROME