WHAT IS HYPER-EOSINOPHILIC SYNDROME (HES)?
Hyper-eosinophilic syndrome (HES) is a rare disease and defined by persistent hyper-eosinophilia (>1500 per microliter) and evidence of eosinophil-mediated organ damage or dysfunction.1,2
Potentially fatal disorders associated with HES include1:
THE ROLE OF EOSINOPHILIC IMMUNE DYSFUNCTION IN HYPER-EOSINOPHILIC SYNDROME
Dysregulation of biological mechanisms involved in eosinophil
recruitment and activation can lead to end-organ damage due to
eosinophil-mediated tissue damage.2
CLINICAL CONSEQUENCES OF HYPER-EOSINOPHILIC SYNDROME (HES)
Hyper-eosinophilic syndrome can manifest as tissue-specific or
widespread organ damage, resulting in diverse symptoms. Worsening of
clinical features, or flares, can occur during treatment or
Organ involvement in hypereosinophilic sydnrome2
*Includes cardiac and vascular involvement1.