EOSINOPHILIC IMMUNE DYSFUNCTION
ACROSS INFLAMMATORY DISEASES
EOSINOPHILIC ESOPHAGITIS (EoE)

Eosinophilic
asthma (EA)

Chronic rhinosinusitis with nasal polyps (CRSwNP)

Eosinophilic
esophagitis (EoE)

Eosinophilic granulomatosis with polyangiitis (EGPA)

Hyper eosinophilic
syndrome (HES)

WHAT IS EOSINOPHILIC ESOPHAGITIS (EoE)?

Eosinophilic esophagitis (EoE) is a chronic, inflammatory disorder of the esophagus characterized by eosinophilic inflammation and symptoms related to esophageal dysfunction.^1-3

Symptoms associated with eosinophilic esophagitis include^1,2,4,5:

Dysphagia
Upper abdominal pain

Chest pain
Painful swallowing
Food impaction

Incidence^6,7

Approximately 1-20 new cases per
100,000 people per year

Estimated Prevalence⁸

22.7 cases per 100,000
(95% CI 12.4-36.0)

THE ROLE OF EOSINOPHILIC IMMUNE DYSFUNCTION IN EOSINOPHILIC ESOPHAGITIS

Dysregulated immune responses lead to the recruitment and activation of eosinophils,
potentially causing eosinophilic inflammation and symptoms associated with
esophageal dysfunction.^9-11

Adapted from O’Shea KM, et al. Gastroenterology. 2018.⁸

IMPACT OF EOSINOPHILIC ESOPHAGITIS ON PATIENTS

Eosinophilic esophagitis is a lifelong, progressive disease that can significantly impact patients’ quality of life.^12-14

ASTRAZENECA IS COMMITTED TO UNCOVERING THE ROLE OF EOSINOPHILIC IMMUNE DYSFUNCTION IN EOSINOPHILIC ESOPHAGITIS.

Eosinophilic granulomatosis
with polyangiitis

EOSINOPHILIC IMMUNE DYSFUNCTIONACROSS INFLAMMATORY DISEASESEOSINOPHILIC ESOPHAGITIS (EoE)