EOSINOPHILIC IMMUNE DYSFUNCTION
ACROSS INFLAMMATORY DISEASES

EOSINOPHILIC ASTHMA (EA)

Eosinophilic
asthma (EA)

Chronic rhinosinusitis with nasal polyps (CRSwNP)

Eosinophilic
esophagitis (EoE)

Eosinophilic granulomatosis with polyangiitis (EGPA)

Hyper eosinophilic
syndrome (HES)

WHAT IS EOSINOPHILIC ASTHMA (EA)?

Eosinophilic asthma is a common type of asthma characterized by high levels of eosinophils that can cause airway inflammation.1-3

 Up to 10% of people

with asthma have
severe asthma4

Up to 70% of severe

asthma patients
have eosinophilic asthma* 5

*Majority of patients with severe asthma (Grade 3 = most likely eosinophilic) had blood eosinophil count (BEC) ≥300 cells/μL OR were on anti-IL-5/IL-5R therapy. Severe disease was also characterised as BEC ≥ 150-300 cells/μL and being on maintenance oral corticosteroid (OCS), or the presence of ≥ 2 nasal polyps (NP), elevated fractional nitric oxide (FeNO) and late onset.

 

THE ROLE OF EOSINOPHILIC IMMUNE DYSFUNCTION IN EOSINOPHILIC ASTHMA

Eosinophils are key effector cells in eosinophilic asthma, where immune system
dysfunction leads to eosinophilic inflammation in the airway tissue.6-8

 

Increasing eosinophil levels in the airway are associated with increasing
severity of asthma.9

 

Eosinophilic asthma patients are at risk of more frequent exacerbations, poorer asthma
control, and lower lung function.10-12

Eosinophilic inflammation in the airway tissue7,13-16

 

Eosinophilic Inflammation in the Airway Tissue
Eosinophilic Inflammation in the Airway Tissue

In eosinophilic asthma, immune cells catalyzed by allergic or nonallergic triggers can lead
to the production of various cytokines. The cytokines produced by these cells
can contribute to the recruitment, activation, and survival of eosinophils.11,16-18

Cytokines are signaling proteins that are usually less than 80kDa in size. Through extracellular signalling, these proteins regulate a wide range of functions, including innate and acquired immunity, hematopoiesis, inflammation and repair, and proliferation.19

EOSINOPHILS ARE KEY EFFECTOR CELLS AND COULD BE THE DRIVER OF A PATIENTS SEVERE ASTHMA.6-8

HOW DO YOU IDENTIFY EOSINOPHILIC ASTHMA?

Patients with eosinophilic asthma may experience the following clinical characteristics11,20:

Identify Eosinophilic Asthma
Identify Eosinophilic Asthma

IT IS IMPORTANT TO RULE OUT EOSINOPHILS AS A DRIVER OF SEVERE DISEASE IN YOUR ASTHMA PATIENTS.