Eosinophilic immune dysfunction (EID) can be characterized as the dysregulation of biological mechanisms involved with eosinophil recruitment and activation.1
EOSINOPHILS ARE KEY EFFECTOR CELLS*2
Activated eosinophils can contribute to disease pathology through several mechanisms and play a key role in the self-perpetuating cycle of inflammatory damage in a range of diseases.1-4
CYCLE OF EOSINOPHILIC INFLAMMATION 1,5-8
Note: this diagram is a simplified depiction of the multiple pathways that can result in eosinophilic inflammation.
ECP=eosinophil cationic protein; EDN=eosinophil-derived neurotoxin; EPX=eosinophil peroxidase; IL=interleukin;
MBP=major base protein; TGF=transforming growth factor; T2=Type 2
*When activated effector cells modulate downstream immune and inflammatory signaling.